Applications are invited for a Postdoctoral Research Associate to investigate the formation together with the chemical and biochemical properties of DNA clustered base lesions induced by oxidative processes. The research will involve the synthesis, the characterization and the measurement of the damaged nucleoside or oligonucleotide together with assessment of biological features (repair, replication,) of the latter substrates, using a variety of biophysical (UV and IR spectroscopy, mass spectrometry, NMR, chromatography,) and biochemical (electrophoresis, enzymatic processing, sequencing,) techniques.

Applicants with a relevant PhD in Chemistry or Biochemistry, a strong background in bio-organic chemistry and biochemistry of nucleic acids and a desire to work in a multidisciplinary environment could apply. The net salary will be within the range of 24000 to 26000 euros per annum, depending on the qualification and experience. The position, integrated in a European Marie Curie Research Training Network (CLUSTOXDNA RTN / 2004-07) is only available for European candidates at the exception of French citizen. This is a 1-year contract with the possibility of extension up to 18 months, starting on Spring 2005.

Applications, including a full CV, a motivation letter and the names of 2 referees who can be contacted prior interview, should be send to: Dr Jean Cadet, CEA Grenoble - Laboratoire des Lesions des Acides Nucleiques, SCIB-DRFMC, 17, rue des Martyrs, 38054 Grenoble Cedex 9, France. Tel: 33(0)438784987 - Fax: 33(0)438785090 - Email: