EUROPA CORDIS
     
 

Mid-Term ClustoxDNA Meeting

October 29th - November 1st 2006

Gandia (Valencia), Spain

PROGRAM

 

 

 

29 october, Sunday

 

9:00-10:40 Chairperson: Miguel Miranda

 

9:00 – 10:00 Gary B. Schuster

Georgia Tech, Atlanta , USA

“Long-distance electron transfer in DNA: reaction and mechanism

 

10:00 – 10:40 Jean Cadet, Thierry Douki, Didier Gasparutto, Jean-Luc Ravanat

CEA, Grenoble , France

"Oxidatively generated damage to DNA: from model compounds to the cell”

 

10:40 – 11:00 Coffee Break

 

 

11:00-13:10 Chairperson: Thanasis Gimisis

 

11:00 – 12:00 Tetsuro Majima

Osaka University , Japan

“Charge transport in DNA”

 

12:00 – 12:40 Chryssostomos Chatgilialoglu

Consiglio Nazionale delle Richerche, Bologna, Italy

Tautomerism in the guanyl radical

 

12:40 – 13:10 Panagiotis Kaloudis

Consiglio Nazionale delle Richerche, Bologna, Italy

“One electron reduction of nucleosides”

 

13:10 – 17:00 FREE TIME

 

 

17:00-18:40 Chairperson: Chryssostomos Chatgilialoglu

 

17:00 – 18:00 Nicholas Geacintov, Vladimir Shafirovich

New York University , USA

“Electron transfer, free radicals, and oxidative DNA damage”

 

18:00 – 18:40 Thanasis Gimisis, Crina Cismas, Antonio Salgado

National Kapodistrian University of Athens , Greece

“Structure determination of DNA lesions through independent synthesis and protein crystallography”

 

18:40 – 18:50 Pause

18:50-19:50 Chairperson: Antonio Salgado

 

18:50 – 19:20 Raul Perez Ruiz, Panagiotis Kaloudis, Thanasis Gimisis

National Kapodistrian University of Athens , Greece

“Generation of 8-oxodGuo radicals from photolabile precursors”

 

19:20 – 19:50 Cecilia Paris, Noureddine Belmadoui.

Universidad Politecnica de Valencia , Spain

“Photooxidation of the adenine base in dAdo-ketoprofen dyads: Photoproduct and transient spectroscopy studies.”

 

 

 

30 October, Monday

 

 

9:00-10:40 Chairperson: Suzana Encinas Perea

 

9:00 – 10:00 Hiroshi Sugiyama

Kyoto University , Japan

“Probing electron transfer process using 5-bromouracil-containing DNA”

 

10:00 – 10:40 Miguel Miranda, Virginie Lhiaubet-Vallet

Universidad Politecnica de Valencia , Spain

“Photosensitized thymine damage in DNA”

 

10:40 – 11:00 Coffee Break

 

 

11:00-13:00 Chairperson: Crina Cismas

 

11:00 – 11:40 Aaron Alt, Thomas Carell

Ludwig-Maximilians- Universitat Munchen , Germany

“DNA repair at atomic resolution”

 

11:40 – 12:10 Antonio Manetto, Dimitris Georganakis, Thanasis Gimisis, Leondios Leondiadis, Thomas Carell, Chryssostomos Chatgilialoglu.

Ludwig-Maximilians- Universitat Munchen , Germany

“Independent generation of C5'-nucleosidyl radicals in thymidine and 2'-deoxyguanosine”

 

12:10 – 12:40 Jerome Trzcionka

Universidad Politecnica de Valencia , Spain

Double role of a carprofen derivative as DNA photosensitizer: thymine dimerization and model oxetane cycloreversion

 

12:40 – 13:00 Noureddine Belmadoui, Peggy Regulus, Jean-Luc Ravanat, Didier Gasparutto, Jean Cadet.

CEA, Grenoble , France

“New clustered DNA lesions”

 

13:30 EXCURSION

 

 

 

 

31 October, Tuesday

 

 

9:00-10:40 Chairperson: Jean Cadet

 

9:00 – 10:00 Eugenia Dogliotti

Istituto Superiore di Sanita, Rome, Italy

“Oxidative DNA damage: mechanisms and relevance for human disease”

 

10:00 – 10:40 Peter O'Neill, Siobhan Cunniffe, Shaun Byrne, Colin Pearson, Naoya Shikazono, Martine Lomax

MRC Harwell, Didcot , United Kingdom

Radiation-induced clustered DNA damage: friend or foe?

 

10:40 – 11:00 Coffee Break

 

 

11:00-13:10 Chairperson: Peter O'Neill

 

11:00 – 12:00 Steven R. Tannenbaum

Massachussetts Institute of Technology, Cambridge , USA

“DNA damage induced by NO and its reaction products”

 

12:00 – 12:40 Herve Menoni, Dimitar Angelov

Bulgarian Academy of Sciences, Sofia , Bulgaria

“ATP dependent chromatin remodeling and DNA repair”

 

12:40 – 13:10 Herve Menoni, Stefan Dimitrov, Philippe Bouvet, Dimitar Angelov

Bulgarian Academy of Sciences, Sofia , Bulgaria

“BER of single and clustered oxidative lesions within in vitro reconstituted nucleosomal templates”

 

 

13:10 – 17:00 FREE TIME

 

 

 

 

17:00-18:40 Chairperson: Dimitar Angelov

 

17:00 – 18:00 Arne Klungland, Elisabeth Larsen, Line M. Nordstrand, Jeannette Ringvoll

Rikshospitalet University Hospital , Oslo , Norway

“Endogeneous damage to DNA; studies in gene-targeted mice”

 

18:00 – 18:40 Andriy Khobta, Bernd Epe

University of Mainz , Germany

Inactivation of a protein gene by oxidative DNA lesions

 

18:40 – 18:50 Pause

 

 

18:50-19:50 Chairperson: Boleslaw Karwoski

 

18:50 – 19:20 Sophie Mourgues, Martine Lomax, Peter O'Neill

MRC Harwell, Didcot , United Kingdom

“Unravelling the pathways involved in the repair of an abasic site and a single-strand break within DNA clustered damage sites”

 

19:20 – 19:50 Sophie Bellon, Siobhan Cunniffe, Martine Lomax, Peter O'Neill

MRC Harwell, Didcot , United Kingdom

“Mutability of clustered DNA damage containing thymine glycol”

 

20:00 – 21:00 Business Meeting